中文版 | English
CSpace
Single-molecular detection of polysaccharides with chemically-modified nanopores
Cai, Yao1; Liang, Liyuan2; Wang, Sen2; Wang, Deqiang2; Cui, Hongliang2
2019
摘要Carbohydrate is an important energy source for human body. Among them, saccharides are the main energy for all living organisms to maintain their life activities, and hold some special physiological activities compared with other nutrients. In consideration of their significance in biological process and structural intricacy, a new precise and reliable technique for their structure identification and discrimination is highly desired. In this work, covalently-modified solid-state nanopores (SSN) have been employed for the detection of polysaccharides with a sample concentration of 5 ng/μL under 150 mV of bias, the experimental findings suggested that polysaccharides have different perforation behavior in chemically-modified nanopores compared with that in bare ones due to specific interactions between polysaccharides and modified inner pore surface, in addition, oligo- and polysaccharides exhibited evident distinct translocation characteristics. The results highlight the applicability of SSN approach for the determination of polysaccharides with high accuracy. © 2019 IEEE.
语种英语
DOI10.1109/3M-NANO46308.2019.8947361
会议(录)名称9th IEEE International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale, 3M-NANO 2019
页码257-260
收录类别EI
会议地点Zhenjiang, China
会议日期August 4, 2019 - August 8, 2019