中文版 | English
CSpace
Nondestructive Thickness Inspection of Capsule Coating by Terahertz Time-Domain Spectroscopy
Chang, Tianying1,2; Guo, Qijia2; Liu, Lingyu1; Cui, Hong-Liang2,3
2018-11-01
摘要Accurate online measurement of capsule coating's thickness is desirable because coating is one of the key factors to control the release of active pharmaceutical ingredients. Terahertz time-domain spectroscopy offers a novel and potentially useful technique to examine coatings in terms of its thickness and uniformity quickly and nondestructively. However, online measurement usually requires the simultaneous determination of the upper and bottom parts of the cylindrical shell, in either the reflectio or transmission mode. There is no method for accurate thickness determination in this two-layer structure of capsule coating simultaneously. Improved matched Me is introduced to obtain each layer's thickness for capsule coating with high resolution and accuracy by the terahertz time-domain spectroscopy, without adjusting the fecal point. This method can determine the thicknesses of both the upper and under layers of the capsule coating with high accuracy in a single measurement, whereas traditional method based on time delays cannot identify the thickness due to the low signal-to-noise ratio from the under layer.
关键词Capsule coating matched filter (MF) thickness determination terahertz time-domain spectroscopy (THz-TDS)
DOI10.1109/TTHZ.2018.2867265
发表期刊IEEE TRANSACTIONS ON TERAHERTZ SCIENCE AND TECHNOLOGY
ISSN2156-342X
卷号8期号:6页码:688-695
通讯作者Chang, Tianying(tchang@jlu.edu.cn)
收录类别SCI
WOS记录号WOS:000453572200017
语种英语