KMS Chongqing Institute of Green and Intelligent Technology, CAS
| Detection of oligonucleotides based on terahertz spectroscopy and microstructure | |
Tang, Mingjie ; Zhang, Mingkun; Yan, Shihan; Xia, Liangping; Yang, Zhongbo; Wei, Dongshan; Cui, Hong-Liang; Du, Chunlei
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| 2016 | |
| 摘要 | DNA mutations are analyzed by terahertz (THz) spectroscopy in a label-free manner. The 5 base mutations from the 3'-terminus on single stranded 17nt oligonucleotides have first been detected based on the microchannel. The mutations have also been validated based on the split-ring resonators (SRRs). The results clearly demonstrate the ability of THz spectroscopy combined with microstructure for label-free detection of base mutations of DNA biomolecules. This study has proved that the THz spectroscopy can be considered as a prospective diagnostic tool for studying the interaction of molecules such as DNA mutations. © 2016 IEEE. |
| 语种 | 英语 |
| DOI | 10.1109/3M-NANO.2016.7824991 |
| 会议(录)名称 | 6th IEEE International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale, IEEE 3M-NANO 2016
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| 页码 | 35-38 |
| 收录类别 | EI |
| 会议地点 | Chongqing, China |
| 会议日期 | July 18, 2016 - July 22, 2016 |
