中文版 | English
CSpace
Sulfamethoxazole, tetracycline and oxytetracycline and related antibiotic resistance genes in a large-scale landfill, China
Song, Liyan1,6; Li, Lei1; Yang, Shu2; Lan, Jiwu3; He, Haijie3; McElmurry, Shawn P.4; Zhao, Youcai5
2016-05-01
摘要Landfills are likely to be important reservoirs of antibiotics and antibiotic resistant genes (ARGs) as they receive unused and unwanted antibiotics and ARGs in municipal solid waste (MSW). The distribution, transportation and dynamics of antibiotics and ARGs in landfills remain largely unknown. In the present study, 3 antibiotics - sulfamethoxazole (SMX), tetracycline (TC), and oxytetracycline (OTC) - and their related ARGs (sulI and tetO) were quantified in 51 refuse samples from different depths at 8 locations within a large-scale landfill in central China. The average concentration of OTC was the highest, up to 100.9 +/- 141.81 mu g/kg (dw, n = 48), followed by TC (63.8 +/- 37.7 mu g/kg, n = 40), and SMX (47.9 +/- 8.1 mu g/kg, n = 30). Both sulI and tetO were detected in all samples. Of the ARGs, sul1 (-3.06 +/- 1.18, n = 51, log(10) ARGs/16SrDNA) was more abundant than tetO (-4.37 +/- 0.97) in all refuse samples (p < 0.05). Both sulI and tetO negatively correlated to refuse age, suggesting they are attenuated during landfill stabilization. OTC and TC positively correlated to tetO (r = 0.41, p < 0.01) and sulI (r = 0.29, p = 0.04), respectively. Chemical conditions (e.g. moisture content and nitrate concentrations) within the refuse correlated to antibiotics and ARGs suggesting environmental factors impact the distribution of antibiotics and ARGs in landfill matrix. This study is the first comprehensive in situ landfill study to connect the concentrations of antibiotic residues to ARGs. (C) 2016 Elsevier B.V. All rights reserved.
关键词Landfill Refuse Antibiotics Antibiotic resistant genes (ARGs) Distribution
DOI10.1016/j.scitotenv.2016.02.007
发表期刊SCIENCE OF THE TOTAL ENVIRONMENT
ISSN0048-9697
卷号551页码:9-15
通讯作者Song, LY (reprint author), 266 Fangzhen Ave,Shuitu High Tech Pk, Chongqing 400714, Peoples R China.
收录类别SCI
WOS记录号WOS:000372589800002
语种英语