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	Association of blood heavy metal concentrations with hearing loss: a systematic review and meta-analysis
	Yang, T.1,2,3,4; Chen, H. J.1,2,3,4; Zhang, C. Y.1,2,3,4; He, D.1,2,3,4; Yuan, W.1,2,3,4
	2024-02-01
摘要	Objectives: This study aimed to assess the associations between blood heavy metal concentrations and hearing loss.Study design: This was a systematic review and meta-analysis.Methods: A comprehensive literature search was performed using Embase, PubMed, Web of Science, Cochrane Library, China National Knowledge Infrastructure, Chinese Biomedical Literature, Wanfang and Weipu databases. Ten studies were included, and a random or fixed-effects model was used for the meta-analysis. Review Manager 5.4 software was used for data synthesis, and Stata 15.1 software was used for the publication bias and sensitivity analyses. Results: Blood lead concentrations were significantly and substantially associated with hearing loss (mean difference (MD) = 1.14; 95% confidence interval [CI] = 0.03, 2.26; P = 0.04; I2 = 81%), and iron deficiency was significantly related to hearing loss (MD =-0.42; 95% CI =-0.66,-0.18; P = 0.12; I2 = 60%).Conclusions: These results suggest an association between blood heavy metal concentrations and hearing loss. However, there were limitations: confounding factors, lack of description for the specific methods of blinding and independent verification of case definition, limited sample size, Chinese publications comprising half of the primary data and the lack of assessment of the relationship between different blood heavy metal concentrations and the severity of hearing loss. Therefore, larger and well-designed prospective cohort studies are required for further exploration.(c) 2023 The Authors. Published by Elsevier Ltd on behalf of The Royal Society for Public Health. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
关键词	Heavy metals Hearing loss Meta-analysis Systematic review
DOI	10.1016/j.puhe.2023.10.019
发表期刊	PUBLIC HEALTH
ISSN	0033-3506
卷号	227页码:95-102
通讯作者	Yuan, W.(weiyuan175@sina.com)
收录类别	SCI
WOS记录号	WOS:001146490900001
语种	英语