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Nanopore single-molecule analysis of biomarkers: Providing possible clues to disease diagnosis
Chen, Xiaohan1,2; Zhou, Shuo1,2; Wang, Yunjiao1,2; Zheng, Ling1,2,3; Guan, Sarah4; Wang, Deqiang1,2; Wang, Liang1,2,5; Guan, Xiyun6
2023-05-01
摘要Biomarker detection has attracted increasing interest in recent years due to the minimally or noninvasive sampling process. Single entity analysis of biomarkers is expected to provide real-time and accurate biological information for early disease diagnosis and prognosis, which is critical to the effective disease treatment and is also important in personalized medicine. As an innovative single entity analysis method, nanopore sensing is a pioneering single-molecule detection technique that is widely used in analytical bioanalytical fields. In this review, we overview the recent progress of nanopore biomarker detection as new approaches to disease diagnosis. In highlighted studies, nanopore was focusing on detecting biomarkers of different categories of communicable and noncommunicable diseases, such as pandemic COVID-19, AIDS, cancers, neurologic diseases, etc. Various sensitive and selective nanopore detecting strategies for different types of biomarkers are summarized. In addition, the challenges, opportunities, and direction for future development of nanopore-based biomarker sensors are also discussed.
关键词Nanopore Biomarkers Analytical bioanalytical methods Single -molecule analysis Human diseases Lab assays and diagnosis
DOI10.1016/j.trac.2023.117060
发表期刊TRAC-TRENDS IN ANALYTICAL CHEMISTRY
ISSN0165-9936
卷号162页码:20
通讯作者Wang, Liang(wangliang83@cigit.ac.cn) ; Guan, Xiyun(xguan5@iit.edu)
收录类别SCI
WOS记录号WOS:000984595000001
语种英语