KMS Chongqing Institute of Green and Intelligent Technology, CAS
| In Situ Cell Detection Using Terahertz Near-Field Microscopy | |
Li, Zaoxia1; Zang, Ziyi1; Wang, Jie1; Lu, Xingxing1; Yang, Zhongbo2,3 ; Wang, Huabin2,3; Cui, Hong-Liang1,2,3 ; Yan, Shihan2,3
| |
| 2022-09-01 | |
| 摘要 | The photoconductive antenna microprobe-based terahertz (THz) near-field scanning microscope has proven to overcome the diffraction limit and demonstrated the potential in distinguishing cellular types and states. Here, using the onion epidermal cells as a sample model, detection of single epithelial cell in the onion skin has been realized at amplitude signal around 1 THz. The boundaries of the target cells in a monolayer onion epidermis are clearly depicted with the spatial resolution of 9 mu m (lambda/33). Differentiated THz dielectric response shows clearly the distinctive intracellular and intercellular regions, mainly related to the hiowater distribution and cellular heterogeneity, which can be used for in situ subcellular identification. This finding may have significant implications for the advancement of THz near-field high-resolution bioimaging technology. |
| 关键词 | Biowater distribution cellular heterogeneity in situ detection near-field imaging terahertz (THz) |
| DOI | 10.1109/TTHZ.2022.3170010 |
| 发表期刊 | IEEE TRANSACTIONS ON TERAHERTZ SCIENCE AND TECHNOLOGY
 |
| ISSN | 2156-342X |
| 卷号 | 12期号:5页码:457-463 |
| 通讯作者 | Cui, Hong-Liang(hcui@jlu.edu.cn) ; Yan, Shihan(yanshihan@cigit.ac.cn) |
| 收录类别 | SCI |
| WOS记录号 | WOS:000849261000007 |
| 语种 | 英语 |
