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Eradicating intracellular MRSA via targeted delivery of lysostaphin and vancomycin with mannose-modified exosomes
Yang, Xiaohong1,2; Xie, Beibei2; Peng, Haibo2; Shi, Gongming2; Sreenivas, Banne2; Guo, Jian2; Wang, Chenhui2; He, Yun2
2021-01-10
摘要Intracellular methicillin-resistant Staphylococcus aureus (MRSA) is extremely difficult to remove by common antibiotics, leading to infection recurrence and resistance. Herein we report a novel exosome-based antibiotic delivery platform for eradicating intracellular MRSA, where mannosylated exosome (MExos) is employed as the drug carrier and preferentially taken up by macrophages, delivering lysostaphin (MExoL) and vancomycin (MExoV) to intracellular pathogens. Combination of MExoL and MExoV eradicated intracellular quiescent MRSA. Moreover, MExos rapidly accumulated in mouse liver and spleen, the target organs of intracellular MRSA, after intravenous (IV) administration. Thus, the MExos antibiotic delivery platform is a promising strategy for combating intracellular infection.
关键词Exosomes Surface functionalization Antibiotics Targeted delivery Intracellular infection
DOI10.1016/j.jconrel.2020.11.045
发表期刊JOURNAL OF CONTROLLED RELEASE
ISSN0168-3659
卷号329页码:454-467
通讯作者Wang, Chenhui(wangchenhui@cqu.edu.cn) ; He, Yun(yun.he@cqu.edu.cn)
收录类别SCI
WOS记录号WOS:000626334700033
语种英语