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In Vivo Toxicity Assessment of Laminarin Based Silver Nanoparticles from Turbinaria ornata in Adult Zebrafish (Danio rerio)
Renuka, Remya Rajan1; Ravindranath, Radhika Rajasree Santha1,4; Raguraman, Vasantharaja1; Yoganandham, Suman Thodhal1,2,3; Kasivelu, Govindaraju1; Lakshminarayanan, Aranganathan1
2020
摘要Silver nanoparticles synthesized using laminarin from Turbinaria ornata were subjected to acute toxicity in adult zebrafish. LC50 concentration of L-AgNPs and C-AgNPs at 96 h was noted to be 25.22 and 19.93 mg/L. To find out the fundamental toxicity mechanisms of L-AgNPs and C-AgNPs, the half of LC50 concentration 12.61 and 9.96 mg/L was exposed to adult zebrafish for 14 days respectively. There are no cytological changes in L-AgNPs whereas cytological changes were observed in gills, brain and liver tissues of C-AgNPs. The results concluded a plausible symbol for oxidative stress in zebrafish. The activities of antioxidant enzyme superoxide dismutase, catalase and glutathione peroxidase were decreased significantly in the C-AgNPs exposed while L-AgNPs showed no significant difference when compared to control. ICP-OES analysis of gills, liver and brain demonstrated that L-AgNPs and C-AgNPs revelation for 14 days resulted in enhanced silver uptake compared to fish treated with control are discussed in detail.
关键词Laminarin Silver nanoparticles Toxicity Turbinaria ornata ICP-OES Zebrafish (Danio rerio)
DOI10.1007/s10876-019-01632-6
发表期刊JOURNAL OF CLUSTER SCIENCE
ISSN1040-7278
卷号31期号:1页码:185-195
通讯作者Ravindranath, Radhika Rajasree Santha(radhiin@gmail.com)
收录类别SCI
WOS记录号WOS:000513242600015
语种英语